Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Heroin addicts that live in a tent.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days, or she will be on the streets.

Extreme hoarder Floyd must clear his hoard or risk losing his three-year-old son.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Sean must overcome recent tragedies in his life before he loses all the progress he made over the last two years; Dottie struggles to stay on track while maintaining her family life.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

Follows the struggles of overweight people as they try to shed the pounds, and how they feel about their weight loss progress.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Tanisha weighs around 600-lbs, and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight, or she will never see her grandchildren grow up.

With the support of his fiancée, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Eight women cope with their incarceration in Gwinnett County Jail; one woman prepares for her release.

Nine women try to cope with their incarceration; a woman awaits trial for five years.

A young mother faces the idea of seeing her son through visitation glass; an inmate promises not to return but finds herself back in jail; a desperate inmate only needs a small amount of money to get released.

A current inmate learns that her son has died in a car crash; an inmate's first Mother's Day behind bars; female inmate almost nine months pregnant.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

Bethany is pregnant by her unemployed boyfriend; Cecily fears her pregnancy.

Ashley struggles with three children, one with cerebral palsy and a stepson, and she is afraid to reveal that she is pregnant; Amatulla is embarrassed to be pregnant again.

Kelly's history of miscarriages; Lauren fears her father.

Kanchana fears having a baby; Susannah's third child with a jobless husband.

A mother becomes a recluse when every sound becomes deafeningly loud; a man's career is in jeopardy when he gets drunk without touching a drop of alcohol.

A dad is accused of child abuse when doctors discover his baby has broken bones; a vibrant teenage girl is unable to eat and is wasting away before her mother's eyes.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A surgical resident puts her training to the test when a mugging survivor arrives with two bullet wounds.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A surgical resident puts her training to the test when a mugging survivor arrives with two bullet wounds.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

Staff treats patient injured while engaging in risky behavior at night.

Medical staff treats patient injured in a car wreck involving multiple vehicles.

A child has celiac disease and an intolerance to gluten; a woman's seizures stop after her left frontal lobe is removed.

A child with Hurler's Disease undergoes a stem cell transplant procedure; a woman is diagnosed with Myasthenia Gravis; a pacemaker regulates a man's cardiac arrhythmia.

A young boy's body does not produce the correct antibodies; a woman loses the ability to walk.

A young girl has trigeminal neuralgia; a woman seeks a reason for her rapid weight gain and other bodily changes.

A couple's Halloween cemetery adventures go wrong; two musicians get busy after band rehearsal and land in the ER; baffling symptoms lead a nurse to believe one male model's gift could be his curse.

A couple lands in the ER after making love while skydiving; a quickie at a wake goes terribly wrong; an early morning romp for two nurses.

A backstage quickie at a body building competition; a soldier's welcome home; a sneaky couple has fun where they were told not to.

A boyfriend is forced to spill a secret when a couple's first time encounters failure; a man's balance problem; a firefighter has a ball and ends up speechless.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With pop-up facts and behind-the-scenes secrets; Brittany's genetic condition causes head-to-toe bumps; Leonardo has a fist-size growth on his head; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With pop-up facts and behind-the-scenes secrets; Brittany's genetic condition causes head-to-toe bumps; Leonardo has a fist-size growth on his head; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Chay has eaten his way to 600 pounds to cope with the emotional turmoil of his childhood; he loses his emotional support and searches for new strength to take control of his life.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame, and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

At 600 pounds, Ashley has to move home, so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

Charles replaces one addiction with another when he quits doing hard drugs; his BMI is over 100, and he can't stop eating; he needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

Charles replaces one addiction with another when he quits doing hard drugs; his BMI is over 100, and he can't stop eating; he needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

At 600 pounds, Ashley has to move home, so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylor is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

A man with a mysterious hard growth on his foot and a dancer who returns for an encore surgery keep Dr. Brad and Dr. Ebonie on their toes.

A man who broke his foot three times and never saw a doctor hopes Dr. Ebonie can provide him with some help; a woman with a strange growth that looks like burnt cauliflower visits Dr. Sarah; one of Dr. Brad's most shocking patients returns.

Dr. Ebonie and Dr. Brad treat a woman who has a foot she says is cursed; a man who has an extraterrestrial on his toe; a woman who has a very cranky callus.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

Born with Goldenhar Syndrome, Austin and Elena have been bullied for looking different, and feel isolated from other kids.

A young boy struggles to breathe.

A child's brain contains a strange mass; doctors fear the worst until a radiologist makes an observation.

A man experiences vomiting, heart palpitations, weakness and general malaise.

Doctors suspect a woman in pain of being neurotic.

A knee injury leaves Lindsay addicted to painkillers.

A 22-year-old heroin addict has been a substance abuser since elementary school.

Josh is a 37-year-old meth addict; his addiction began at age 15.

A 20-year meth addict's addiction worsens after the sudden death of his father.

Donny has been to jail twice because of his hoard; Joyce finds comfort in her doll collection, while others see it as creepy.

It takes less than a week for 16-year-old Haley to fill a bedroom with stuff; her parents hope that a visit with an extreme hoarder will scare their daughter straight.

A former ventriloquist turns her career into an obsession; Harold has trouble being a good father when his daughter isn't allowed in his home.

Larina's compulsive hoarding puts her on the verge of losing her 10-year-old daughter.

Donny has been to jail twice because of his hoard; Joyce finds comfort in her doll collection, while others see it as creepy.

It takes less than a week for 16-year-old Haley to fill a bedroom with stuff; her parents hope that a visit with an extreme hoarder will scare their daughter straight.

A former ventriloquist turns her career into an obsession; Harold has trouble being a good father when his daughter isn't allowed in his home.

Larina's compulsive hoarding puts her on the verge of losing her 10-year-old daughter.

Josh is a 37-year-old meth addict; his addiction began at age 15.

A 20-year meth addict's addiction worsens after the sudden death of his father.

Milla is dependent on her children and seeks to lose enough weight to be able to walk; Charity is mired in a deep depression, while her daughter, Charly, battles a food addiction; they strive to turn things around and reach their goal weight.

Olivia suffers an unexpected loss; James strives to reach his goal of skin surgery and have a fulfilling relationship.

Zsalynn struggles between fighting her weight and fighting for her marriage; Christina releases the negativity in her life and finally begins to live.

In the fourth year of his weight-loss journey, Sean struggles to get past the loss of his mother and live on his own; Dr. Now intervenes to control Sean's eating for a time.

Liz has gone from being bedbound with lymphedemas on both legs to standing and walking; if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart; with facts and bonus scenes.

In order to keep pace with her daughter Charly's impressive weight loss, Charity must do something she's never done and find a way to go it alone.

Steven's dysfunction escalates, pushing his relationship with Dr. Nowzaradan; his brother Justin takes the leap to go to Houston to finally accept help.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Nathan is shedding pounds and heading back to work as a teacher following his weight-loss surgery; however, his wife Amber can't seem to do the same as she struggles to qualify for a second surgery to update one she had years ago.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Nathan is shedding pounds and heading back to work as a teacher following his weight-loss surgery; however, his wife Amber can't seem to do the same as she struggles to qualify for a second surgery to update one she had years ago.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

Nikki finds her career as a costume designer threatened by immobility, so she undergoes gastric bypass and confronts the emotional causes for her eating.

Ashley confronts medical setbacks and struggles to get past the trauma that ignited her eating disorder.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.