A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.

Season 1 skin removal patients try to cope with life one year after undergoing near total body transformations.

Checking in with Season 2 folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Checking in with season two folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

A year after the Anderson family started their weight loss journey, they find that the honeymoon period is over as they begin to struggle; their 600-pound cousin Shavonne wants to follow in their footsteps.

Shavonne calls out the family for not losing weight; Naomi gets devastating news that might derail her goals for good; Drew attempts to re-enter the dating world for the first time in a decade; Chitoka tries to get back on track.

The members of the Anderson family work through their issues in group therapy; Chitoka and Shavonne face the painful memories that have kept them from losing more weight.

Shavonne undergoes high-risk bariatric surgery; Chitoka struggles to lose enough weight to be approved for skin tightening surgery; Drew works up the courage to go on another date; the family throws a party for Shavonne to reveal her weight loss.

Fall from a ladder; young car-crash victims.

Gunshot victims; homeless children with colds; seizure; stroke victim.

A family of three and the drunk driver who hit them; burn victim; crash victim; baby with sickle-cell anemia.

Car-crash victims; smoker fights for breath; uncooperative patient.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man gains 100 pounds of water weight.

A woman has pain with her menstrual cycle; growths on body.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man gains 100 pounds of water weight.

A woman has pain with her menstrual cycle; growths on body.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

Riah has been addicted to baby wipes since she was 15 and goes through 500 a day, using them instead of showering; Brea has been addicted to eating sand for the past five years.

Danielle has been addicted to vapor rub for more than 20 years, going through more than 30 jars, inhalers and patches every week; 19-year-old Allison has been eating tires for the past six years, consuming 14 pounds every month.

Keisha is addicted to chewing on urine-soaked diapers; 50-year-old Vladimir is obsessed with using leeches.

Tom spends at least six hours a day cycling; Divya spends her time searching for dead animals on the side of the road and stuffing them.

Theresa has been eating rocks for more than 20 years and cannot stop; Tamara carries around her childhood pillow Boo everywhere she goes.

Meet Kailyn has been eating plastic every day for more than eleven years; meet Gloria who has taken her addiction to bleach to the extreme by bathing in it daily.

Caryn eats over 900 cat treats and several cans of wet food every day; Alicia is addicted to smelling mothballs for 15 years, keeping them all over her house and in her purse.

Bertha's addition to nail polish has her drinking up to five bottles everyday for five years; Jamie can't stop digging in her ears.

Kirstie's addiction to dirt has her eating it everyday for the past 30 years; Ayanna can't stop growing her toenails.

Jillian has been addicted to smelling pine cleaner for two years and can't go more than 15 minutes without a smell; Scott is obsessed with picking up dead animals from the road.

Trina and her husband Mike have done nearly 7,000 coffee enemas over the last two and a half years; Lisa has been addicted to licking her cat and eating clumps of hair for three years.

Asha hasn't cut her 21-foot long hair for nearly 25 years and spends up to 6 hours a day grooming her ten-pound locks; Margaret has stung herself over 50,000 times with bees.

A family of four is on the brink of collapse under the weight of the parents' hoarding; a man denies he's addicted to auctions and garage sales.

Two women seek help for their compulsive hoarding problems.

Bennie and Rhonda have lived decades of compulsive hoarding that have driven their loved ones away.

Laura and Margaret are both mothers and extreme hoarders; their parallel obsessions have made them prisoners in their own homes while tearing their families apart.

Deborah and Mary both start hoarding in the wake of personal tragedies; ever since Deborah killed her drug-addicted boyfriend in self-defense, she and her son have lived amid growing piles of trash and unused possessions.

9/11 trauma was the trigger for one woman; the lasting effects of a brain hemorrhage.

A man whose body is eating itself hopes surgery can cure him and save his life; a gymnast who lost her leg to cancer hopes her new prosthetic will keep her performing; the shortest living man in the world looks for a diagnosis.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man whose body is eating itself hopes surgery can cure him and save his life; a gymnast who lost her leg to cancer hopes her new prosthetic will keep her performing; the shortest living man in the world looks for a diagnosis.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Paula has built a wall around herself to push people away; when she suddenly loses a loved one she can no longer ignore the threat of losing her own life.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten to derail his progress.

Pauline is 51-years-old and nearly 700 pounds; her addiction to food has taken over the life of her son and primary caretaker.

At 24-years-old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

The revelation of a man's adoption catapults his search for his biological roots, but his son's DNA only deepens the mystery; a woman enlists Chris' help to find the son she placed for adoption, hoping her decision was not in vain.

Sisters searching for their birth mother hope Chris can uncover the mystery of why they were taken from her when they were young; Lisa helps a mother find the daughter she placed for adoption, hoping the adoptive family she chose was the right one.

Lisa helps a man find answers about his adoption; a breast cancer survivor searches for her birth mother.

Chris unwraps the mystery of a woman's origins, which at a Korean orphanage; Lisa desperately searches for a woman's only child, hoping it will heal her.

At 24 inches tall and a mere 12 pounds, 26-year-old Jyoti Amge is the smallest woman in the world; Jyoti is in the United States for work and to explore American culture, but she also hopes to find a doctor for a serious health issue.

A 16 inch Nepalese elder lobbies to get the record for world's smallest man.

Four-year-old twins Arthur and Heitor are joined at the waist. Are they strong enough for surgery? Plus, an extreme form of vitiligo has left a woman's body both black and white.

Kaitlyn is home alone in the tub when she suddenly feels her baby's head crowning; Myrna suffers a seizure and collapses into a coma.

Fifteen months after her son's birth, Emily fears her appendix has burst and her mother rushes her to the emergency room.

Dana is having debilitating stomach pains at work; the paramedics arrive just in time to deliver a baby.

A 20-year-old woman suffers abdominal pain while at work; while waiting it out she realizes she is delivering a baby.

After a negative pregnancy test, Monique delivers a baby in her bathroom.

A flight attendant has mysterious pains in her stomach; she is stunned to learn she is in labor.

After staying home from class, Katlyn makes a trip to the bathroom, which brings her to her knees in pain, and she realizes that she is in labor.

A woman in top shape suddenly has debilitating cramps; at the hospital she is stunned to learn she is pregnant and in labor.

Back pain is typical for Andrea, but when she starts bleeding severely, she must call 911.

Jasmine is forced to call an ambulance when she experiences abdominal cramps; an emergency c-section reveals a shocking surprise.

Debbie knows the OCD drives her hoarding; Jeff doesn't believe he is a hoarder.

Linda's family is on the edge of collapse because of her hoarding; Norski has overcome addiction but can she kick the hoarding habit.

Michael has six weeks to clean his house or he will go to jail; a motivational speaker can not manage her own life.

Debbie turned to hoarding after a confession ended her marriage; with illness in her family, Julie hoards to ease the pain.

Phyllis' neighbors are complaining about the trash piling up outside; Faye realizes her hoard is killing her.

Brad's hoarding has taken over his mobile home; Mary has been evicted and has just weeks to clean out her stuff.

Michael has six weeks to clean his house or he will go to jail; a motivational speaker can not manage her own life.

Debbie turned to hoarding after a confession ended her marriage; with illness in her family, Julie hoards to ease the pain.

Phyllis' neighbors are complaining about the trash piling up outside; Faye realizes her hoard is killing her.

Brad's hoarding has taken over his mobile home; Mary has been evicted and has just weeks to clean out her stuff.

Debbie knows the OCD drives her hoarding; Jeff doesn't believe he is a hoarder.

Linda's family is on the edge of collapse because of her hoarding; Norski has overcome addiction but can she kick the hoarding habit.

A farmer's arm gets stuck in a corn picker; a woman's home project turns into a nightmare as doctors try to save her life; a young man's life changes in an instant on a California beach.

A mom sends a text while driving and wakes up with a guardrail through her car; young woman partying falls off a boat into a spinning propeller;a professional sword swallower nearly makes the ultimate sacrifice.

A boulder falls on a woman rock climbing; a California woman falls on her bag of knitting needles; an adrenaline junkie nearly ends his thrill-seeking life attempting to break a speed record.

Truck mechanic Bruce is crushed by a truck; high school student Hannah joins her friends on top of a car to go "car surfing."

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

A woman's face-lift goes terribly wrong; a hospital chaplain's sudden personality change; a pregnant woman's life-threatening symptoms need urgent treatment.

A student's head is impaled by a trophy deer's antlers; a semi-conscious car crash victim; a woman with an allergic reaction.

A man injured in a medieval role playing battle has a sword impaled in his head; a critically ill patient is so afraid of germs he won't allow doctors to treat him; two patients with the same life-threatening symptoms.

A baby has large blisters and a high fever; a teenager begins to gain weight at an alarming rate.

A college student has a large blister; nurse has back spasms.

A woman suddenly loses a breast; a baby cries and vomits when fed.

After moving houses, and months of strange behavior, 11-year-old Sammy stops walking and only hops. Can doctors bring him out of the bizarre world he is slipping into?

Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.

A baby has strange spots all over; a dad's muscle weakness.

A woman suddenly loses a breast; a baby cries and vomits when fed.

After moving houses, and months of strange behavior, 11-year-old Sammy stops walking and only hops. Can doctors bring him out of the bizarre world he is slipping into?

Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.

A baby has strange spots all over; a dad's muscle weakness.

A baby has large blisters and a high fever; a teenager begins to gain weight at an alarming rate.

A college student has a large blister; nurse has back spasms.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

Amber is 23, over 600-lbs, and relies on her family and boyfriend for even simple needs; her fear of dying young is so overwhelming that she decides to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

Susan, 37-year-old woman, has never lived on her own because of her weight, is finally seeking help to get out on her own.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

Shakyia was always chubby, but now she does not leave the house and makes no effort; her older sister rallies her to Houston to meet Dr. Now and lose weight, but she is in for a shock when her mother decides that caring for her is just too much.

Surgery enables Teretha to return to family in Detroit, but it soon threatens to undo all her progress; Chad is back on the road, but his old diet is a risk.

After losing 250lbs, Nikki is on her way to skin surgery, but when a close friend dies from weight loss surgery, Nikki's progress is derailed by fears.

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Charles replaces one addiction with another when he quits doing hard drugs; his BMI is over 100 and he can't stop eating; he needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Charles replaces one addiction with another when he quits doing hard drugs; his BMI is over 100 and he can't stop eating; he needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

Jaclyn has a lump on the back of her head that causes her emotional distress; Shane has a growth between his eyes that could put him in danger at his electrician job; Brittany has seen multiple doctors about the sores on her body with no answers.

Stacey's shoulder growth prevents her from being the playful teacher she once was; Matthew worries that his mysterious shin rash may be dangerous.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshipper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

With lumpy lipomas and cysts-a-plenty, Dr. Lee and her staff will have their hands full during one of their busiest days of the year.

Roger returns with his gigantic nose growths in the hope that Dr. Lee and her colleagues can help before it's too late; Christine has lost her essence due to a large growth on her shoulder; Tiffany has a recurring cyst on her eyelid.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.